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    Reversal of protein chemical aging by enzymatic deglycation

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    Researchers froze the simplest amino acid to nearly minus 260°C and bombarded it with radiation that mimics cosmic rays — and it formed peptides, the building blocks of proteins, under conditions that exist before stars and planets are born

    Researchers froze the simplest amino acid to nearly minus 260°C and bombarded it with radiation that mimics cosmic rays — and it formed peptides, the building blocks of proteins, under conditions that exist before stars and planets are born

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    Researchers froze the simplest amino acid to nearly minus 260°C and bombarded it with radiation that mimics cosmic rays — and it formed peptides, the building blocks of proteins, under conditions that exist before stars and planets are born

    Researchers froze the simplest amino acid to nearly minus 260°C and bombarded it with radiation that mimics cosmic rays — and it formed peptides, the building blocks of proteins, under conditions that exist before stars and planets are born

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水中の4-AP溶液におけるグリシンとグリシルグリシンの動態の解明:温度にわたる実験とDFT研究の統合

iLIFE by iLIFE
2025年8月12日
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以下の文を日本語のニュース記事として翻訳しました。

—

現在の研究では、0.001、0.003、0.005 mol·kg–1のモラリティを持つ4-アミノピリジン(4-AP)の水溶液を溶媒媒体として利用し、常圧下で293.15 Kから313.15 Kの温度範囲におけるアミノ酸(AAs)グリシンおよびグリシルグリシンの物理化学的特性を探求しました。密度および粘度の実験的測定により、見かけのモル体積(Vϕ)、限界部分モル体積(Vϕ0)、移動体積(ΔtrVϕ0)、ジョーンズ・ドール粘度B係数、粘性流動の活性化自由エネルギー(Δμ10#およびΔμ20#)などの重要な熱力学的および輸送パラメータの評価が可能となりました。これらのデータは、4-APの濃度が増加するにつれて溶質-溶媒相互作用が強化されることを示しており、コースフィアオーバーラップモデルと一致しています。グリシンおよびグリシルグリシンは、4-APの存在下で水溶媒に対して構造を破壊する効果を示し、水の固有構造に対する撹乱を示唆しました。補完的な蛍光分光分析により、アミノ酸濃度の系統的な変化を通じて結合定数の推定が可能となり、1H NMR分光法は4-APとアミノ酸間の疎水性相互作用の存在に関する洞察を提供しました。これらの実験的知見は、計算モデルによってさらに裏付けられ、これらのシステムを支配する相互作用のダイナミクスに関する一貫した分子レベルの視点を提供しました。

—

この翻訳は、科学的な内容を正確に伝えることを目的としています。

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