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合成還元グリシン経路による一炭素固定がカルビン回路の収量を上回る

iLIFE by iLIFE
2025年2月27日
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以下の文を日本語のニュース記事として翻訳します。

—

**要約**
フォルメートのような一炭素原料は、持続可能な微生物による食品、燃料、化学物質の生産において有望な再生可能基質となる可能性があります。ここでは、Cupriavidus necatorのエネルギー効率の悪いカルビン・ベンソン・バスハム回路を、フォルメートとCO2での成長のためによりエネルギー効率の良い還元グリシン経路に置き換えました。ケモスタットで、私たちの改良株は野生型よりも17%高いバイオマス収量を達成し、カルビン回路を使用する自然のフォルマトロフよりも高い収量を示しました。これは、持続可能でバイオベースの生産を実現するための合成代謝の可能性を示しています。

**関連情報**
酸素耐性の還元グリシン経路は、酵母Komagataella phaffiiにおいてメタノール、フォルメート、CO2を同化します。
2023年11月27日公開
CO2固定の増加により、酵母における3-ヒドロキシプロピオン酸の高炭素収量生産が可能になります。
2024年2月21日公開
還元グリシン経路はDesulfovibrio desulfuricansの自給的成長を可能にします。
2020年10月9日公開

**主な内容**
再生可能な電気化学的に得られたフォルメートに対して高い微生物収量を実現するための有望な戦略は、よりATP効率の良い合成経路の実装です。最も有望な合成経路の一つである還元グリシン経路(rGlyP)は、フォルメートに対する最もATP効率の良い好気的経路です。

—

この翻訳は、元の内容を日本語で分かりやすく伝えることを目的としています。

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