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自然のホウ酸コールマナイトによる前生物条件下での再現可能なアラ-グリオリゴマー化

iLIFE by iLIFE
2025年8月8日
in GLYCINE
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以下は、提供された内容を日本語のニュース記事風に翻訳したものです。

—

**抽象**

複雑なペプチドのアビオジェネシス(生物の起源に関する問題)は、特定のアミノ酸配列が調節メカニズムなしにどのように形成されるかが不明であるため、未解決の問題です。結晶鉱物は、複製可能なオリゴマー化プロセスを維持するためのテンプレートスキャフォールドを提供した可能性があります。私たちは、天然の有機親和性ホウ酸塩であるコールマナイト(CaB3O4(OH)3·H2O)が、活性化されたグリシンとアラニンをN-カルボキシアナハイドリドとして用いることで、Gly-Alaオリゴマー化を促進し、明確な一次配列を持つAG8、G7AG、G7GAのストランドをそれぞれ8%、47%、45%の割合で生成することを示しました。これらのGlyリッチな配列は機械的に柔軟であり、古代のポリペプチドにおけるアミノ酸ループの駆動において重要な構造的役割を果たした可能性があります。実際、これらの配列は、シアノバクテリアや熱耐性細菌を含む祖先の生物に属する、構造的または輸送機能を利用するタンパク質に繰り返し現れます。私たちの結果は、前生物的に妥当な環境下で穏やかな条件で数日間のインキュベーションを行うことで、短い明確なアミノ酸配列の一貫した合成が可能であることを示しています。

—

この翻訳は、元の内容を日本語で要約し、ニュース記事の形式に整えたものです。

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